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Cat. No. | Product Name | Target | Signaling Pathways |
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T8747 |
Levofloxacin hydrochloride
|
DNA gyrase; Topoisomerase | DNA Damage/DNA Repair |
Levofloxacin hydrochloride 是一种广谱的第三代氟喹诺酮类抗生素,是氧氟沙星的光学活性 L-异构体,具有抗菌活性。左氧氟沙星通过细菌细胞壁扩散并通过抑制 DNA 促旋酶(细菌拓扑异构酶 II)起作用,这是一种 DNA 复制、RNA 转录和细菌 DNA 修复所需的酶。 DNA 促旋酶活性的抑制导致细菌细胞生长受阻。 | |||
T6828 |
ZL0420
|
Epigenetic Reader Domain | Chromatin/Epigenetic |
ZL0420 是有效且选择性的 BET 溴结构域 4 (BRD4) 抑制剂,对 BRD4 的溴结构域 (BD) 具有纳摩尔结合亲和力。ZL0420 对 BRD4 BD1和 BRD4 BD2 的IC50分别为 27 nM 和 32 nM。 | |||
T60072 |
ZL0590
|
Epigenetic Reader Domain | Chromatin/Epigenetic |
ZL0590 是一种有效的特异性 BD1-BRD4 抑制剂 (IC50 = 90 nM),具有抗炎活性。 | |||
T25465 |
GS143
GS-143,GS 143 |
IκB/IKK; E1/E2/E3 Enzyme; NF-κB | NF-κB; Ubiquitination |
GS-143 是选择性的IκBα泛素化抑制剂,抑制 SCFβTrCP1介导的IκBα泛素化作用,IC50=5.2 μM。GS143 抑制NF-κB 的活化和靶基因的转录,并且不抑制蛋白酶体的特性,并具有抗哮喘作用。 | |||
T1451 |
Levofloxacin hydrate
左氧氟沙星半水合物,Levaquin hydrate,Cravit hydrate,Quixin hydrate,Levofloxacin Hemihydrate,Tavanic hydrate,Iquix hydrate |
DNA gyrase; Topoisomerase; Antibacterial; Antibiotic | DNA Damage/DNA Repair; Microbiology/Virology |
Levofloxacin hydrate (Cravit hydrate) 是抗生素化合物,抑制细菌DNA 旋转酶活性。 | |||
T77045 |
Itepekimab
REGN-3500,SAR-440340 |
Others | Others |
Itepekimab (REGN-3500) 是一种有效的抗 IL-33 的单克隆抗体。Itepekimab 在体内实验中可减少气道炎症和相关组织损伤,可用来研究哮喘疾病。 | |||
T11179 |
Elubrixin
SB-656933 |
IL Receptor; CXCR | Autophagy; GPCR/G Protein; Immunology/Inflammation |
Elubrixin (SB-656933) 是一种有效和特异性的 CXCR2 和 IL-8 受体拮抗剂。 Elubrixin 可用于炎症性疾病的研究,例如炎症性肠病和气道炎症。 | |||
T10110 |
3-CPs
3-Carbethoxypsoralen,3-Ethoxycarbonylpsoralen |
Antibiotic | Microbiology/Virology |
3-CPs (3-Carbethoxypsoralen) 是一种博来霉素诱导的小鼠肺纤维化血清型荚膜多糖,属于补骨脂,可干扰抗体介导的细菌杀伤作用。3-CPs 可延缓博来霉素诱导的小鼠肺纤维化,可用于研究气道炎和哮喘。 | |||
T36503 |
Sodium Hydrogen Sulfide (hydrate)
|
Others | Others |
Sodium Hydrogen Sulfide (hydrate) 与一氧化氮一样,是一种重要的气体介质,对哺乳动物的免疫、神经、心血管和肺系统有重要影响。Sodium Hydrogen Sulfide (hydrate)是一种H2S 供体,常用于细胞和整个动物实验系统。例如,它被用来证明H2S 促进中性粒细胞迁移,减少气道炎症,保护神经轴突、心脏和肠道免受化学或缺血再灌注损伤。 | |||
T28878 |
Sul-121 HCl
Sul-121 Hydrochloride |
||
Sul-121 has anti-oxidative capacity. In experimental chronic obstructive pulmonary disease (COPD) models, Sul-121 HCl inhibits airway inflammation and hyperresponsiveness (AHR) prospectively through inhibition of oxidative stress. | |||
T32156 |
Indimilast
|
||
Indimilast is used to inhibit phosphodiesterase IV that regulates lung inflammation and causes bronchiectasis by increasing intracellular cyclic adenosine 3', 5'-monophosphate in airway smooth muscle and inflammatory cells. Potential to treat chronic obst | |||
T41121 |
Elubrixin tosylate
SB-656933 tosylate,Elubrixin tosylate |
||
Elubrixin tosylate (SB-656933 tosylate) is a high-potency, selective, competitive, and reversible CXCR2 antagonist, as well as an antagonist of the IL-8 receptor. It effectively inhibits upregulation of neutrophil CD11b (with an IC50 of 260.7 nM) and shape change (with an IC50 of 310.5 nM). This compound holds promise for the study of inflammatory diseases, including inflammatory bowel disease and airway inflammation. | |||
T78371 |
Ac2-26 ammonium
|
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Ac2-26 ammonium是一种具抗炎作用的annexin 1 N末端肽。该化合物能够通过伴侣介导的自噬(CMA)机制降低溶酶体中的IKKβ蛋白含量,从而改善肺缺血再灌注损伤,并在哮喘大鼠模型中抑制气道炎症以及高反应性的表现。 | |||
T76320 |
FIZZ-1 (32-51) (mouse)
|
||
FIZZ-1 (32-51) (mouse) 是一种富含半胱氨酸的分泌性蛋白,主要在过敏性气道炎症中被巨噬细胞、支气管上皮细胞及II型肺泡上皮细胞高度表达,具有对肺成纤维细胞的抗凋亡功能,广泛应用于过敏性肺炎的研究领域。 | |||
TP2008 |
Lyn peptide inhibitor
|
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Cell-permeable inhibitor of Lyn-dependent effects of the IL-5 receptor. Blocks binding of Lyn tyrosine kinase to βc subunit of IL-3/GM-CSF/IL-5 receptors, blocking Lyn activation. Inhibits IL-5 receptor-mediated eosinophil differentiation and survival in | |||
T69262 | ABE171 | ||
ABE171, also known as NVP-ABE171, is a potent and novel phosphodiesterase 4 inhibitor with anti-inflammatory activities. NVP-ABE171 inhibited the activity of phosphodiesterase 4A, 4B, 4C, and 4D with respective IC(50) values of 602, 34, 1230, and 1.5 nM. In human cells, NVP-ABE171 inhibited the eosinophil and neutrophil oxidative burst, the release of cytokines by T cells, and the tumor necrosis factor-alpha release from monocytes, in the nanomolar range. NVP-ABE171 inhibited the airway neutrop... | |||
T38100 |
Betamethasone 21-phosphate (sodium salt hydrate)
|
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Betamethasone 21-phosphate is a synthetic glucocorticoid.1It prevents increases in macrophage and eosinophil numbers in bronchoalveolar lavage fluid (BALF) and decreases in blood leukocyte numbers in a guinea pig model of parainfluenza-3 viral infection when administered at a dose of 8 mg/kg but does not prevent airway hyperresponsiveness after infection.2Betamethasone 21-phosphate inhibits cell infiltration into the aqueous humor in a rat model of endotoxin-induced uveitis when administered top... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3872 |
Nodakenin
紫花前胡苷,(+)-Marmesinin |
AChE | Neuroscience |
Nodakenin ((+)-Marmesinin) 是一种Peucedanum decursivum Maxim 根中的主要香豆素苷。它能够抑制乙酰胆碱酯酶活性,IC50=84.7 μM。 | |||
TN2244 |
Sulfuretin
硫黄菊素 |
NF-κB; Autophagy | Autophagy; NF-κB |
Sulfuretin 是竞争性单酚酶和二酚酶活性抑制剂,IC50=13.64 μM。它通过抑制NF-κB 通路来抑制炎症反应。 它可用于过敏性气道炎症的研究。它减少氧化应激、血小板聚集和诱变。 | |||
T5758 |
sphondin
6-甲氧基当归素,牛防风素,牛防风素 |
COX; Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Sphondin 具有抗惊厥、抗炎和抗增殖活性,对 IL-1beta 诱导的 A549 细胞中 COX-2 蛋白水平和 PGE(2) 释放的增加具有抑制作用。 | |||
T6567 |
Levofloxacin
Levaquin,Cravit,Tavanic,Fluoroquinolone,左氧氟沙星,(-)-Ofloxacin |
Topoisomerase; Antibacterial; Antibiotic | DNA Damage/DNA Repair; Microbiology/Virology |
Levofloxacin (Fluoroquinolone) 是合成的氟喹诺酮类抗生素,有抑制细菌DNA 旋转酶的超螺旋活性的作用,能阻止DNA 复制。 | |||
T4S2164 |
Narirutin
Naringenin-7-O-rutinoside,Isonaringin,芸香柚皮苷,柚皮芸香苷 |
Others; Antibacterial | Microbiology/Virology; Others |
Narirutin (Naringenin-7-O-rutinoside) 是从Citrus unshiu 中分离的活性成分之一,具有抗氧化和抗炎活性。它是一种具有抗结核效力的shikimate 激酶抑制剂。 | |||
TMA1570 |
Sappanone A
|
NF-κB; Nrf2 | Immunology/Inflammation; NF-κB |
Sappanone A 是一种高异黄烷酮,通过调节 Nrf2 和 NF-κB 表现出抗炎作用。Sappanone A 可以减轻卵清蛋白引起的哮喘中的过敏性气道炎症。 | |||
T2978 |
Mogroside V
|
AMPK | Chromatin/Epigenetic; PI3K/Akt/mTOR signaling |
Mogroside V 是三萜糖苷,是非糖类甜味剂,甜度比蔗糖甜高300倍。它具有抗氧化,抗糖尿病和抗癌作用。 | |||
T6S0077 |
Byakangelicol
|
COX | Immunology/Inflammation; Neuroscience |
Byakangelicol 是一种分离自白芷的白三醇,能够抑制环加氧酶-2的表达及活性,从而减少白细胞介素-1β诱导的 A549 细胞中前列腺素 E2 的释放。它可用于研究气道炎症。 | |||
T40787 |
Platyconic acid A
|
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Platyconic Acid A, derived from changkil saponins extracted from platycodon grandiflorum, is a potent compound employed for studying the mitigation of airway inflammation. | |||
TN4819 | (-)-Praeruptorin A | ATPase; IL Receptor; Calcium Channel; P-gp | Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience |
(-)-Praeruptorin A has anti-inflammatory, anti-contractile and anti-hyperplasia activities, it exerts distinct relaxant effects on isolated rat aorta rings dependent on endothelium and nitric oxide synthesis;it also can significantly suppress airway inflammation and airway remodeling induced by ovalbumin challenge, and is a potential candidate for the treatment of asthma. (-)-Praeruptorin A resensitizes Pgp-mediated MDR (Pgp-MDR) cancer cells to cancer drugs. |